PBOND: Web Server for the Prediction of Proline and Non-Proline cis / trans Isomerization

PBOND is a web server that predicts the conformation of the peptide bond be-tween any two amino acids. PBOND classifies the peptide bonds into one out of four classes, namely cis imide(cis-Pro), cis amide(cis-nonPro), trans imide (trans-Pro)and trans amide(trans-nonPro). Moreover, for every prediction a reliability index is computed. The underlying structure of the server consists of three stages:(1)feature extraction,(2)feature selection and(3)peptide bond clas-sification. PBOND can handle both single sequences as well as multiple sequences for batch processing. The predictions can either be directly downloaded from the web site or returned via e-mail. The PBOND web server is freely available at http://195.251.198.21/pbond.html.

作 者： Konstantinos P. Exarchos Themis P. Exarchos Costas Papaloukas Anastassios N. Troganis Dimitrios I. Fotiadis   作者單位： Konstantinos P. Exarchos,Themis P. Exarchos(Unit of Medical Technology and Intelligent Information Systems, Department of Computer Science, Uni-versity of Ioannina, Ioannina 45110, Greece;Institute of Biomedical Research and Technology, Centre for Research and Technology-Thessaly(CERETETH), Larissa 41222, Greece;Department of Medical Physics, Medical School, University of Ioannina, Ioannina 45110, Greece)

Costas Papaloukas(Unit of Medical Technology and Intelligent Information Systems, Department of Computer Science, Uni-versity of Ioannina, Ioannina 45110, Greece;Department of Biological Applications and Technology, University of Ioannina, Ioannina 45110, Greece)

Anastassios N. Troganis(Department of Biological Applications and Technology, University of Ioannina, Ioannina 45110, Greece)

Dimitrios I. Fotiadis(Unit of Medical Technology and Intelligent Information Systems, Department of Computer Science, Uni-versity of Ioannina, Ioannina 45110, Greece;Institute of Biomedical Research and Technology, Centre for Research and Technology-Thessaly(CERETETH), Larissa 41222, Greece) 

刊 名： 基因組蛋白質(zhì)組與生物信息學報（英文版）  英文刊名： GENOMICS、PROTEOMICS & BIOINFORMATICS  年，卷(期)： 2009 7(3)  分類號： Q5  關鍵詞： peptide bond   cis/trans isomerization   support vector machine  

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