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微囊藻毒素-LR致小鼠肝細(xì)胞DNA-蛋白質(zhì)交聯(lián)作用的研究
摘要： 為探討微囊藻毒素-LR致小鼠肝細(xì)胞的DNA-蛋白質(zhì)交聯(lián)作用,將20只昆明雄性小鼠隨機(jī)分為4組:1個(gè)對照組和3個(gè)染毒組,采用腹腔注射進(jìn)行染毒7d,染毒劑量分別為3.0、6.0和12.01zg·kg-1,檢測小鼠肝細(xì)胞DNA-蛋白質(zhì)交聯(lián)程度.結(jié)果顯示,3.0、6.0和12.0μg·kg-1囊藻毒素-LR均可導(dǎo)致小鼠肝細(xì)胞顯著的DN-蛋白質(zhì)交聯(lián)作用(與對照組相比,p<0.01,p<0.01,p<0.05),當(dāng)微囊藻毒素為6.0g·kg-1時(shí),這種作用最明顯. Abstract： This study investigated the changes of DNA-protein crosslinks (DPC) in hepatic cells of mice that exposed to microcystin-LR (MCLR). Twenty male Kun Ming mice were divided into four groups: one control and three exposure groups. The control group were treated with saline and the exposure groups were treated with 3.0, 6.0 and 12.0μg·kg-1 MCLR respectively by injected intraperitoneally (i.p.) for 7d. Results showed that the DNA-protein crosslinks induced by MCLR exposures at 3.0, 6.0 and 12.0pμg·kg-1 were significant (p<0.01, p<0.01, p<0.05) compared with the control,and the 6.0μg·kg-1 exposure group was found to induce DNA-protein crosslinks most. In conclusion. MCLR can induce DNA-protein crosslinks in hepatic ceils of mice at the concentratioas of 3.0, 6.0 and 12.0μg·kg-1. 作 者： 段麗菊 張慧珍 董玲 程學(xué)敏 崔留欣 DUAN Li-ju ZHANG Hui-zhen DONG Ling CHENG Xue-min CUI Liu-xin 作者單位： 鄭州大學(xué)公共衛(wèi)生學(xué)院,鄭州,450001 期 刊： 生態(tài)毒理學(xué)報(bào) ISTIC Journal： ASIAN JOURNAL OF ECOTOXICOLOG 年，卷(期)： 2008, 3(6) 分類號(hào)： X171.5 X173 Keywords： microcytin-LR mouse hepatic cells DNA-protein crosslinks【微囊藻毒素-LR致小鼠肝細(xì)胞DNA-蛋白質(zhì)交聯(lián)作用的研究】相關(guān)文章：
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